ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that GD001 involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes.Here we used a mutational analysis approach to evaluate the relationship between these events.We p