ABCA1 MUTANTS REVEAL AN INTERDEPENDENCY BETWEEN LIPID EXPORT FUNCTION, APOA-I BINDING ACTIVITY, AND JANUS KINASE 2 ACTIVATION

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation

ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that GD001 involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes.Here we used a mutational analysis approach to evaluate the relationship between these events.We p

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Emergence and Evolution of Anthropogenic Landscapes in the Western Mediterranean and Adjacent Atlantic Regions

Socio-ecological systems are complex, dynamic structures driven by cross-scale interactions between climate, disturbance and subsistence strategies.We synthetize paleoecological data to explore the emergence and evolution of anthropogenic landscapes in southwestern Europe and northern Africa.Specifically, we estimate trends in vegetation and fire,

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